Non-contact electric fields inhibit the growth of breast cancer cells in animal models and induce local immune reaction

Alamsyah, Firman and Fadhlurrahman, Ahmad Ghitha and Pello, Jessica Irene Mesak and Firdausi, Nisrina and Nugraheni, Subekti Evi Dwi and Karima, Farah Nadia and Pratiwi, Rarastoeti and Fitria, Laksmindra and Nurhidayat, Luthfi and Taruno, Warsito Purwo (2018) Non-contact electric fields inhibit the growth of breast cancer cells in animal models and induce local immune reaction. ESMO Open, 3 (2). A269. ISSN 2059-7029

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Official URL: https://www.esmoopen.com/article/S2059-7029(20)316...

Abstract

Non-contact electric fields namely Electro-capacitive Cancer Therapy (ECCT) exposure with low intensity and intermediate frequency (100 KHz) exerted between two capacitive electrodes increased the percentage of cell death of MCF-7 (39.45%). In addition, a pilot study of the safety and efficacy of ECCT performed in 9 C3H mice revealed significant tumour shrinkage of more than 67% in size. Histopathological analysis of the mammary glands showed macrophages and other immune cells infiltrate through the blood vessel in the area of breast tumour. This study used bigger sample size to observe the safety and efficacy of ECCT and local immune reaction after exposure.

Item Type:	Article
Additional Information:	This article is presented in the 25th Biennial Congress of the European Association for Cancer Research held on 30 June – 3 July 2018 in Amsterdam (The Netherlands), indexed in Q1 Journal Ranking Index and published by Elsevier Limited on behalf of European Society for Medical Oncology after originally published by BMJ; TURNITIN's similarity index result was checked based on rules stated in "Pedoman Operasional Penilaian Angka Kredit Kenaikan Jabatan Akademik/Pangkat Dosen" (http://lldikti12.ristekdikti.go.id/wp-content/uploads/2019/03/PO-PAK-2019_MULAI-BERLAKU-APRIL-2019.pdf) pp. 23-25
Uncontrolled Keywords:	biology, biotechnology, cancer cells, electro-capacitive cancer therapy (ECCT)
Subjects:	600 Applied sciences & technology > 610 Medicine & health 600 Applied sciences & technology > 610 Medicine & health > 616 Diseases
Divisions:	Universitas Al-Azhar Indonesia (UAI) > Fakultas Sains dan Teknologi (FST) > Biologi
Depositing User:	Rifda Jilan
Date Deposited:	22 Sep 2021 05:25
Last Modified:	22 Nov 2021 10:52
URI:	http://eprints.uai.ac.id/id/eprint/1710

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